Blar i NTNU Open på forfatter "Latz, Eicke"
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Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
Niyonzima, Nathalie; Bakke, Siril S.; Gregersen, Ida; Holm, Sverre; Sandanger, Øystein; Orrem, Hilde Lang; Sporsheim, Bjørnar; Ryan, Liv; Kong, Xiang Yi; Dahl, Tuva Børresdatter; Skjelland, Mona; Sørensen, Kirsten; Rokstad, Anne Mari A.; Yndestad, Arne; Latz, Eicke; Gullestad, Lars; Andersen, Geir Øystein; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Halvorsen, Bente; Espevik, Terje (Peer reviewed; Journal article, 2020)Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) ... -
Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis
Alvarez-Silva, Camila; Schierwagen, Robert; Pohlmann, Alessandra; Magdaleno, Fernando; Uschner, Frank Erhard; Ryan, Patrick; Vehreschild, Maria J. G. T.; Claria, Joan; Latz, Eicke; Lelouvier, Benjamin; Arumugam, Manimozhiyan; Trebicka, Jonel (Peer reviewed; Journal article, 2019)Background: Acquired dysfunctional immunity in cirrhosis predisposes patients to frequent bacterial infections, especially spontaneous bacterial peritonitis (SBP), leading to systemic inflammation that is associated with ... -
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
Zimmer, Sebastian; Grebe, Alena; Bakke, Siril Skaret; Bode, Niklas; Halvorsen, Bente; Ulas, Thomas; Skjelland, Mona; De Nardo, Dominic; Labzin, Larisa I.; Kerksiek, Anja; Hempel, Chris; Heneka, Michael T.; Hawxhurst, Victoria; Fitzgerald, Michael L.; Trebicka, Jonel; Björkhem, Ingemar; Gustafsson, Jan Åke; Westerterp, Marit; Tall, Alan R.; Wright, Samuel D.; Espevik, Terje; Schultze, Joachim L.; Nickenig, Georg; Lütjohann, Dieter; Latz, Eicke (Journal article, 2016)Atherosclerosis is an inflammatory disease linked to elevated blood cholesterol concentrations. Despite ongoing advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains the leading cause ... -
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik; Espevik, Terje (Journal article, 2017)Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a ... -
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik; Espevik, Terje (Journal article; Peer reviewed, 2017)Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a ... -
Dental calculus stimulates interleukin-1β secretion by activating NLRP3 inflammasome in human and mouse phagocytes
Raudales, Jorge Luis Montenegro; Yoshimura, Atsutoshi; Sm, Ziauddin; Kaneko, Takashi; Ozaki, Yukio; Ukai, Takashi; Miyazaki, Toshihiro; Latz, Eicke; Hara, Yoshitaka (Journal article; Peer reviewed, 2016)Dental calculus is a mineralized deposit associated with periodontitis. The bacterial components contained in dental calculus can be recognized by host immune sensors, such as Toll-like receptors (TLRs), and induce ... -
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
Husebye, Harald; Halaas, Øyvind; Stenmark, Harald; Tunheim, G; Sandanger, Øystein; Bogen, B; Brech, A; Latz, Eicke; Espevik, Terje (Journal article; Peer reviewed, 2006)Immune responses are initiated when molecules of microbial origin are sensed by the Toll‐like receptors (TLRs). We now report the identification of essential molecular components for the trafficking of the lipopolysaccharide ... -
Metabolomic profiling reveals distinct and mutual effects of diet and inflammation in shaping systemic metabolism in LDLR<sup>−/−</sup> mice
Lauterbach, Mario A.R.; Latz, Eicke; Christ, Anette (Journal article; Peer reviewed, 2020) -
Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation
Niyonzima, Nathalie; Samstad, Eivind; Aune, Marie Hjelmseth; Ryan, Liv; Bakke, Siril Skaret; Rokstad, Anne Mari; Wright, Samuel; Damås, Jan Kristian; Mollnes, Tom Eirik; Latz, Eicke; Espevik, Terje (Journal article; Peer reviewed, 2015)Chronic inflammation of the arterial wall is a key element in the development of atherosclerosis, and cholesterol crystals (CC) that accumulate in plaques are associated with initiation and progression of the disease. We ... -
Sensing soluble uric acid by Naip1-Nlrp3 platform
Braga, Tarcio Teodoro; Davanso, Mariana Rodrigues; Mendes, Davi; de Souza, Tiago Antonio; de Brito, Anderson Fernandes; Cruz, Mario Costa; Hiyane, Meire Ioshie; de Lima, Dhemerson Souza; Nunes, Vinicius; de Fátima Giarola, Juliana; Souto, Denio Emanuel Pires; Próchnicki, Tomasz; Lauterbach, Mario A.R.; Biscaia, Stellee Marcela Petris; de Freitas, Rilton Alves; Curi, Rui; Pontillo, Alessandra; Latz, Eicke; Camara, Niels Olsen Saraiva (Peer reviewed; Journal article, 2021)Uric acid (UA), a product of purine nucleotide degradation able to initiate an immune response, represents a breakpoint in the evolutionary history of humans, when uricase, the enzyme required for UA cleavage, was lost. ... -
Soluble Uric Acid Activates the NLRP3 Inflammasome
Braga, Tarcio Teodoro; Forni, Maria Fernanda; Correa-Costa, Matheus; Ramos, Rodrigo Nalio; Barbuto, Jose Alexandre; Branco, Paola; Castoldi, Angela; Hiyane, Meire Ioshie; Davanso, Mariana Rodrigues; Latz, Eicke; Franklin, Bernardo S.; Kowaltowski, Alicia J.; Camara, Niels Olsen Saraiva (Journal article; Peer reviewed, 2017)Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome. Soluble uric acid (sUA) is found in high ... -
Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever
Mangan, Matthew S. J.; Gorki, Friederike; Krause, Karoline; Heinz, Alexander; Pankow, Anne; Ebert, Thomas; Jahn, Dieter; Hiller, Karsten; Hornung, Veit; Maurer, Marcus; Schmidt, Florian I.; Gerhard, Ralf; Latz, Eicke (Peer reviewed; Journal article, 2022)Pyrin is a cytosolic immune sensor that nucleates an inflammasome in response to inhibition of RhoA by bacterial virulence factors, triggering the release of inflammatory cytokines, including IL-1β. Gain-of-function mutations ...